- 451 – The Council of Chalcedon adopts the Chalcedonian Creed regarding the divine and human nature of Jesus Christ.
- 1746 – The College of New Jersey (later renamed Princeton University) receives its charter.
- 1797 – One thousand meters (3,200 feet) above Paris, Andre-Jacques Garnerin makes the first recorded parachute jump.
- 1836 – Sam Houston is inaugurated as the first President of the Republic of Texas.
- 1844 – The Great Anticipation: Millerites, followers of William Miller, anticipate the end of the world in conjunction with the Second Advent of Christ. The following day became known as the Great Disappointment.
- 1879 – Using a filament of carbonized thread, Thomas Edison tests the first practical electric incandescent light bulb (it lasted 13.5 hours before burning out). See “Mothers: The Making of Scouts” and find out about the Thomas Edison Scout Award.
- 1907 – Panic of 1907: A run on the stock of the Knickerbocker Trust Company sets events in motion that will lead to a depression.
- 1926 – J. Gordon Whitehead sucker punches magician Harry Houdini in the stomach in Montreal, precipitating his death.
- 1957 – Vietnam War: First United States casualties in Vietnam.
- 1962 – Cuban Missile Crisis: US President John F. Kennedy, after internal counsel from Dwight D. Eisenhower, announces that American reconnaissance planes have discovered Soviet nuclear weapons in Cuba, and that he has ordered a naval “quarantine” of the Communist nation.
- 1966 – The Supremes become the first all-female music group to attain a No. 1 selling album (The Supremes A’ Go-Go)
- 1972 – Vietnam War: In Saigon, Henry Kissinger and South Vietnamese President Nguyen Van Thieu meet to discuss a proposed cease-fire that had been worked out between Americans and North Vietnamese in Paris.
- 1978 – Papal inauguration of Pope John Paul II.
- 1981 – The United States Federal Labor Relations Authority votes to decertify the Professional Air Traffic Controllers Organization for its strike the previous August.
- 1734 – Daniel Boone, American Explorer and hunter (d. 1820)
- 1811 – Franz Liszt, Hungarian pianist and composer (d. 1886)
- 1907 – Jimmie Foxx, American baseball player (d. 1967)
- 1936 – Bobby Seale, American activist, co-founded the Black Panther Party
- 1938 – Christopher Lloyd, American actor
- 1942 – Annette Funicello, American actress and singer (d. 2013)
- 1948 – Lynette Fromme, American attempted assassin of Gerald Ford
- 1741 – William IV, Prince of Orange (b. 1711)
- 1906 – Paul Cezanne, French painter (b. 1839)
- 1934 – Pretty Boy Floyd, American gangster (b. 1904)
See Wikipedia, “October 22.”